Development of the technique for quality control of 1,3-bis(3,4-dicyanophenoxy)benzene by HPLC

Objectives . Determination of target products and byproducts is necessary for the quality control phthalonitrile monomer synthesis as well production scaling performing related kinetic studies. High-performance liquid chromatography (HPLC) a simple affordable method quantitative chemical analysis, which also verifies raw materials. The objective this study was to develop an HPLC technique determining composition reaction mixture in 1,3-bis(3,4-dicyanophenoxy)benzene (DPB). Methods Reversed-phase used quantitatively analyze mixture. Results A rapid analysis monomers their mixtures with reagents developed. Reaction times accumulation were studied. Conclusions successful performance developed allows us recommend it practical applications. results obtained reactors different sizes have good convergence, DPB successfully scaled up intermediate scale equipment.